منابع مشابه
[Clinical evaluation of routinely applied highly sensitive TSH-RIA].
Forty-one routine TSH assays were carried out by applying newly developed, highly sensitive TSH RIA (T. Mori, et al., Folia Endocrinol. Jap., 56: 1231, 1980). B/B0 percent of the least standard point (0.156 microU/ml) was consistently lower than B0 and higher than that of 0.31 microU/ml. The distributions of assayed TSH concentrations in 1394 sera revealed that 34.8% of the total were in an und...
متن کاملRadioimmunoassay of thyroid related hormones and TSH in primary hyperthyroidism.
One hundred and forty seven clinically proven hyperthyroid subjects were studied using radioimmunoassay techniques for the estimation of serum thyroid hormones and pituitaryTSH concentrations. In females toxic goitre was more frequently seen in the age group 21 to 30 years and in males 31 to 40 years. The mean levels for serum T4, T3, FT4 and FT1 were significantly elevated while the mean level...
متن کاملFolding-dependent binding of thyrotropin (TSH) and TSH receptor autoantibodies to the murine TSH receptor ectodomain.
The mouse TSH receptor ectodomain (mTSHR-ecd) was amplified from murine thyroid complementary DNA and ligated into the pAcGP67B insect cell vector, and the nucleotide sequence was confirmed. Employing a baculovirus-insect cell system, the mTSHR-ecd (amino acids 22-415) was expressed as a fusion protein with the gp67 insect cell signal sequence at the NH2-terminus and a C-terminal six-histidine ...
متن کاملTSH screening
That means there is considerable overlap in what we would consider the true euthyroid state in a patient. Hence, a population may be well characterised by this screening process, but it doesn't closely reflect the individual situation. As a result, an abnormal result of the population-based screening should not necessarily translate into an automatic decision on the requirement of treatment. Th...
متن کاملIntracellular entrapment of wild-type TSH receptor by oligomerization with mutants linked to dominant TSH resistance.
TSH resistance is one of the causes of congenital hypothyroidism with thyroid gland in situ. We recently identified families with dominant transmission of partial TSH resistance due to heterozygous inactivating mutations in TSH receptor (TSHR) gene. Although we documented a poor routing of TSHR mutants to the cell membrane, the mechanism responsible for dominant inheritance of partial TSH resis...
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ژورنال
عنوان ژورنال: RADIOISOTOPES
سال: 1979
ISSN: 1884-4111,0033-8303
DOI: 10.3769/radioisotopes.28.7_453